Tom Ripley is paid $1,000 to travel to Italy and persuade Dickie Greenleaf to return to the United States. Claiming to be a former Princeton classmate, he slides into Dickie's life, and a friendship at the seaside turns into a trail of lies and killings.
The route follows the film's order through Ischia and Procida, Anzio, Naples, Rome and Venice. Many places play other places: Ischia and Procida stand in for the fictional village of Mongibello, Anzio plays San Remo, and the "Roman" opera house is in Naples.
The pope is dead, four cardinals have been kidnapped, and a missing vial of antimatter will destroy the Vatican at midnight. The American symbologist Robert Langdon is called in and reads the threat as a path: four altars of the "Path of Illumination", tied to the classical elements, where a cardinal will die each hour from 8 p.m. With Vittoria Vetra, a CERN scientist, he races the clock across Rome — from a Pantheon they wrongly believe holds the first answer to a fountain where a cardinal is being drowned.
This route follows Ron Howard's 2009 film rather than Dan Brown's novel: the Pantheon and Raphael's tomb, the Chigi Chapel in Santa Maria del Popolo, the obelisk in St Peter's Square, Bernini's Ecstasy of Saint Teresa, the Fountain of the Four Rivers, the assassin's lair at Castel Sant'Angelo, and the midnight finale beneath St Peter's. All of it still stands; the caveat is that Rome's diocese refused the crew access to the churches, so several interiors in the film are studio sets.