Prince Shōtoku's temples in Japan run from Tachibana-dera and Asuka-dera in Asuka to Hōryū-ji and Chūgū-ji in Ikaruga, plus Shitennō-ji in Osaka.
The route follows the regent who promoted Buddhism, from the place said to be his birthplace to his palace site at Ikaruga and the embroidery made after his death in 622. Several dates rest on temple tradition rather than firm records, and the birthplace is marked as traditional.
In 1581 the African slave Diogo comes to Kyoto with a Jesuit delegation and is handed to the warlord Oda Nobunaga, who renames him Yasuke and makes him a samurai. That year Nobunaga's army crushes the ninja province of Iga, where the young shinobi Naoe loses her father and inherits his Hidden Blade.
From there the two hunt the same conspiracy across Kansai: the port of Sakai, the temple at Honnō-ji where Nobunaga dies, a kofun in Settsu, the castle of Shōryūji at Yamazaki, the shrines of Yamato, and the Templar recruiting ground of Kii. Most stops are real castles, temples and tombs that the game rebuilds.